On January 14, 2006, US planes bombed the Pakistani village of Damadola in the Bajaur tribal area, about 7km (4.5 miles) from the Afghan border. Ayman al-Zawahiri was thought to be inside, but it was ruled out by the Pakistani intelligence.

The strike killed 18 civilians; eight men, five women and five children. The Pakistani government angrily denounced the attack. Pakistan's Information Minister Sheikh Rashid Ahmed called the attack "highly condemnable" and said the government wanted "to assure the people we will not allow such incidents to reoccur."

The Foreign Ministry issued a statement saying it protested to U.S. Ambassador Ryan Crocker over the "loss of innocent civilian lives."

Thousands of tribesmen staged protests and a mob set fire to the office of a U.S.-backed aid agency in a sign of increasing frustration over a recent series of suspected U.S. attacks along Pakistan's frontier with Afghanistan.

CIA sources claim the agency has all the approvals necessary within its counterterror center in Langley, Virginia to fire missiles within Pakistan when an al-Qaida target is spotted. The agency does not have to check with the White House or with Pakistani authorities or the CIA director. The purpose is to expedite rapid action in the field in case the opportunity is time-sensitive.

from Wikipedia